I'm just going to try out using transactions with the FMDB SQLite iOS wrapper.
The documentation is a little vague on transactions but from having a quick look at some functions I have come up with the following logic:
[fmdb beginTransaction];
// Run the following query
BOOL res1 = [fmdb executeUpdate:@"query1"];
BOOL res2 = [fmdb executeUpdate:@"query2"];
if(!res1 || !res2) [fmdb rollback];
else [fmdb commit];