There are many ways to do this. Here's a very naive one:
var parts = "City, State ZIP".split(/\s+/); // split on whitespace
var city = parts[0].slice(0, parts[0].length - 1); // remove trailing comma
var state = parts[1];
var zip = parts[2];
Here's one that accounts for the presence of spaces in either the city or state or both:
var parts = "san fran bay, new mex state 666666".split(/\s+|,/),
partition = parts.indexOf(""),
city = parts.slice(0, partition).join(" "),
state = parts.slice(partition + 1, -1).join(" "),
zip = parts.pop();
This last one only works if you're lucky enough to be in an environment that supports destructuring assignment:
var city, statezip, state, zip, parts;
[city, statezip] = "Spaced City, New Mexico ZIP".split(/,\s*/);
parts = statezip.split(/\s+/);
zip = parts.pop();
state = parts.join(" ");
None of these perform any validation, of course.