Recently someone mentioned to me that there is a diophantine equation that looks very simple and innocent, but the smallest solution involves numbers of the order $10^{50}$ or something like this. The equation is probably in either 1,2, or 3 varaibles. It has low coefficients, probably all 1 or 2. And the degree is low also, probably 4 or less.

Is there such an equation?

Edit: I think the equation might have been studied by Fermat, but I'm not sure.