The PyWin32 package is a close wrapper around Microsoft Windows API. It was created and is still maintained by Mark Hammond.
Python for Windows Extension (PyWin32) is a close wrapper around Microsoft Windows API. It is so close that you can actually read MSDN documentation and almost directly translate their examples into Python. PyWin32 is actively developed and is supported in Python 2.x and 3.x.
Latest official build can be downloaded here: https://sourceforge.net/projects/pywin32/files/pywin32/
You can get support by joining their mailing list here: http://mail.python.org/mailman/listinfo/python-win32. ActiveState maintains a good copy of PyWin32's documentation: http://docs.activestate.com/activepython/2.7/pywin32/win32_modules.html
Tim Golden has written several add-on packages for this project, such as WMI, winshell and WinSys. These may be browsed here: http://timgolden.me.uk/python/ He also has many tutorials on his website for PyWin32 and his own packages that are well worth the time to learn.