Glanders is a contagious zoonotic infectious disease that occurs primarily in horses, mules, and donkeys. It can be contracted by other animals, such as dogs, cats, pigs, goats, and humans. It is caused by infection with the bacterium Burkholderia mallei.

Other namesEquinia, farcy,[1] malleus[2]
Philadelphia horse fountain, altered to discourage spread of glanders, 1917.
SpecialtyInfectious diseases, veterinary medicine 

Glanders is endemic in Africa, Asia, the Middle East, and Central and South America. It has been eradicated from North America, Australia, and most of Europe through surveillance and destruction of affected animals, and import restrictions. Glanders has not been reported in the United States since 1945, except in 2000, when an American lab researcher had an accidental exposure in the lab.[3] It is a notifiable disease in the UK,[4] although it has not been reported there since 1928.

The term is from Middle English glaundres or Old French glandres, both meaning glands.[5] Other terms include Latin: malleus, Spanish: muermo, German: Rotz and Norwegian: snive.


Signs of glanders include the formation of nodular lesions in the lungs and ulceration of the mucous membranes in the upper respiratory tract. The acute form results in coughing, fever, and the release of an infectious nasal discharge, followed by septicaemia and death within days. In the chronic form, nasal and subcutaneous nodules develop, eventually ulcerating; death can occur within months, while survivors act as carriers.

Cause and transmission

Burkholderia mallei

Glanders is caused by infection with the Burkholderia mallei, usually by ingestion of contaminated feed or water. B. mallei is able to infect humans, so it is classed as a zoonotic agent. Transmission occurs by direct contact with infected animal's body fluid and tissues and entry is through skin abrasions, nasal and oral mucosal surfaces, or inhalation.[6]


The mallein test is a sensitive and specific clinical test for glanders. Mallein (ATCvet code: QI05AR01 (WHO)), a protein fraction of the glanders organism (B. mallei), is injected intradermopalpebrally or given by eye drop. In infected animals, the eyelid swells markedly in 1 to 2 days.

Historical cases and potential use in war

Glanders has been known since antiquity, with a description by Hippocrates around 425 BCE.[7]

From the Middle Ages to the 1900s, glanders was a significant threat to armies.[8][1] Before the Battle of Blenheim in 1704, glanders may have afflicted and greatly diminished the horses of Marshal Tallard's cavalry, helping the Duke of Marlborough win the battle.[9]

Glanders was a significant problem for civilian use of horses, as well. In the 18th-century veterinary hospital at the École Nationale Vétérinaire d'Alfort, glanders was the most common disease among their equine patients and the one most likely to cause death.[10]

Due to the high mortality rate in humans and the small number of organisms required to establish infection, B. mallei is regarded as a potential biological warfare or bioterrorism agent, as is the closely related organism, B. pseudomallei, the causative agent of melioidosis. During World War I, glanders was believed to have been spread deliberately by German agents to infect large numbers of Russian horses and mules on the Eastern Front.[11] Other agents attempted to introduce the disease in the United States and Argentina. This had an effect on troop and supply convoys, as well as on artillery movement, which were dependent on horses and mules. Human cases in Russia increased with the infections during and after WWI. The Japanese deliberately infected horses, civilians, and prisoners of war with B. mallei at the Unit 731 Pingfang (China) Institute and Unit 100 facilities during World War II. The U.S. studied this agent as a possible biological weapon in 1943–44, but did not weaponize it. U.S. interest in glanders (agent LA) continued through the 1950s, except it had an inexplicable tendency to lose virulence in the lab, making it difficult to weaponize. Between 1982 and 1984, the Soviet Union allegedly used weaponized B. mallei during the Soviet–Afghan War.[12]

Vaccine research

No vaccine is licensed for use in the U.S.[13] Infection with these bacteria results in nonspecific symptoms and can be either acute or chronic, impeding rapid diagnosis. The lack of a vaccine for either bacterium also makes them potential candidates for bioweaponization.[14] Together, with their high rate of infectivity by aerosols and resistance to many common antibiotics, both bacteria have been classified as category B priority pathogens by the US NIH and US CDC, which has spurred a dramatic increase in interest in these microorganisms. Attempts have been made to develop vaccines for these infections, which would not only benefit military personnel, a group most likely to be targeted in an intentional release, but also individuals who may come in contact with glanders-infected animals or live in areas where melioidosis is endemic.


  1. Wilkinson, Lise (1981). "Glanders: Medicine and Veterinary Medicine in Common Pursuit of a Contagious Disease". Medical History. 25 (4): 363–84. doi:10.1017/S0025727300034876. PMC 1139069. PMID 7038356. S2CID 4591425.
  2. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
  3. "Laboratory-Acquired Human Glanders --- Maryland, May 2000". Archived from the original on 5 December 2021. Retrieved 29 November 2021.
  4. Department for Environment, Food & Rural Affairs and Animal and Plant Health Agency. "Notifiable diseases in animals". United Kingdom Government. Archived from the original on 7 May 2016. Retrieved 8 April 2016.
  5. "glanders". American Heritage Dictionary of the English Language: Fourth Edition. 2000. Archived from the original on 2008-01-31. Retrieved 2007-05-13.
  6. "Glanders-Transmission". 15 October 2018. Archived from the original on 2011-10-18. Retrieved 2020-09-04.
  7. McGilvray, C. D. (July 1944). "The Transmission of Glanders from Horse to Man". Canadian Journal of Public Health. Canadian Public Health Association. 35 (7): 268–275. JSTOR 41978893.
  8. Lafosse, E.G. (1749). "Preface". Traité sur le véritable siège de la morve des chevaux, et les moyens d'y remédier. Paris: David & Gonichon. It is a well established fact that the great and terrible ravages of glanders are found in the armies; it is certain that during all the wars under which Europe has laboured for 200 years, a very considerable number of horses has been lost through this disease."
  9. Chandler, D. G. (June 1963). "From The Other Side Of The Hill, Blenheim, 1704". Journal of the Society for Army Historical Research. Society for Army Historical Research. 41 (166): 79–93. JSTOR 44222485. However, the incurable murrain[Footnote1] this regiment contracted whilst sharing winter quarters with the French Sommeri Regiment had already put most of the troopers on their own two feet ─ and shortly afterwards this contagion spread to the whole army under the name of the "German sickness" for want of a better diagnosis. [Footnote1] This disease was probably "glanders." Eventually it affected a large part of Tallard's cavalry. The general condition of Marlborough's cavalry at the end of the long march to the Danube contrasted very favourably with the fettle of the French.
  10. Heintzman, Kit (2018). "A cabinet of the ordinary: domesticating veterinary education, 1766–1799". The British Journal for the History of Science. 51 (2): 239–260. doi:10.1017/S0007087418000274. PMID 29665887. S2CID 4947361.
  11. Woods, Lt. Col. Jon B., ed. (April 2005). USAMRIID's Medical Management of Biological Casualties Handbook (PDF) (6th ed.). Fort Detrick, Maryland: U.S. Army Medical Institute of Infectious Diseases. p. 67. Archived from the original (PDF) on 2007-06-09.
  12. Van Zandt, Kristopher E.; Greer, Marek T.; Gelhaus, H. Carl (September 3, 2013). "Glanders: an overview of infection in humans". Orphanet Journal of Rare Diseases. 8: 131. doi:10.1186/1750-1172-8-131. PMC 3766238. PMID 24004906.
  13. "Glanders: Prevention". Archived from the original on 28 March 2016. Retrieved 6 April 2016.
  14. Dance, David Allan Brett (2009). "Melioidosis and Glanders as Possible Biological Weapons". Bioterrorism and Infectious Agents: A New Dilemma for the 21st Century. pp. 99–145. doi:10.1007/978-1-4419-1266-4_4. ISBN 978-1-4419-1265-7.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.